In summary, we demonstrated that modern wheat breeding synergistically improved the above- and belowground traits by selecting haplotypes with synergistic effects in the bi-effect selection blocks. These results fundamentally changed our current understanding of how modern wheat breeding increased grain yields. All the resources generated in this study have been curated in the Wheat Genotype and Phenotype Database (WGPD, http:// resource.iwheat.net/WGPD/), a free, web-accessible, and user- friendly platform
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